Changes in the way research ethics was visualised within the wake of the Nuremberg Trials , led to an environment of protectionism of teams deemed to be vulnerable that was typically legislated or regulated. This resulted in the relative underrepresentation of ladies in scientific trials. In follow this ban was usually applied very broadly to exclude all women. Women, a minimum of those within the baby-bearing years, have been additionally deemed unsuitable analysis subjects as a result of their fluctuating hormonal levels through the menstrual cycle. However, research has demonstrated vital biological differences between the sexes in rates of susceptibility, signs and response to treatment in lots of main areas of health, together with heart disease and a few cancers. These exclusions pose a menace to the application of proof-based mostly drugs to women, and compromise to care offered to both women and men.